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JW Player 5.9.rar


Among many signal pathways, the aberrant activation of Wnt/β-catenin signal is the most important for the occurrence and development of various cancer.179 More than 80% of cancer patients have inactivating mutations of APC or activating mutations of CTNNB1, leading to the messenger molecule β-catenin protein continuing to accumulate in cells, which eventually leads to the excessive activation of Wnt/β-catenin signal and the proliferation of cancer cells.180 As β-catenin is the central player of the canonical Wnt/β-catenin signaling and is frequently mutated in cancers, it is the most attractive target for cancer therapy.181 However, β-catenin has no enzymatic activity and small-molecule binding pockets, and has a large interaction interface with other proteins. Therefore, it is difficult for such small molecule inhibitors to completely inhibit the function of β-catenin.182 Thus, inducing the degradation of β-catenin is an ideal method for treating Wnt/β-catenin signal-related diseases.




JW Player 5.9.rar


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if(typeof JGVideoPlayers=='undefined')JGVideoPlayers=;$.extend(JGVideoPlayers,"83020":"jwplayersrc":"\/extensions\/common\/jscss\/jwplayer.js","jwplayeropts":"flashplayer":"\/extensions\/common\/jscss\/player.swf","file":"https:\/\/s9.imslp.org\/files\/imglnks\/usimg\/e\/ea\/IMSLP83020-PMLP11297-uso20100530-008-brahms-ein-deutsches-requiem-mvtIV.mp3","controlbar":"bottom","width":640,"height":24,"stretching":"uniform","nextid":83021);


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